Angiographic evaluation of the effect of intracoronary abciximab administration in patients undergoing urgent PCI

Francesco Burzotta, Carlo Trani, Filippo Crea, Elisa Romagnoli, Mario Attilio Mazzari, Maria De Vita, Giampaolo Niccoli, Francesco Prati, Antonio Giuseppe Rebuzzi

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Recent data suggest that the intracoronary (IC) administration of a systemic bolus dose of abciximab during PCI may increase the efficacy of this antiplatelet drug. However, the effect of IC abciximab on coronary angiographic flow has been not clarified. Methods: We studied 37 consecutive patients with acute coronary syndromes (ACS) who underwent successful urgent PCI on the target vessel and were treated by an IC abciximab bolus (0.25 mg/kg) prior to the first balloon inflation (Group IC), and 37 matched controls who were treated by intravenous (IV) abciximab bolus at the same dose (Group IV). Corrected TIMI frame count (CTFC) in the culprit and in a non-culprit coronary artery branch was assessed before treatment, immediately after intracoronary administration of abciximab bolus and at the end of the procedure. Results: After administration of abciximab, CTFC significantly decreased from 48 + 37 to 33 + 30 (P = 0.001) in the culprit vessel while in the non-culprit vessel it remained unchanged (16 + 7 pre-treatment and 16 + 7 post-treatment, P = 0.68). Final CTFC was 12 + 4 in Group IC and 14 + 5 in Group IV (P = 0.069). Post-treatment mean peak of the cardiac enzymes showed a trend toward reduction in Group IC compared with Group IV. Conclusions: The IC administration of abciximab bolus acutely decreases CTFC through culprit vessels of patients with ACS undergoing urgent PCI. Further studies evaluating the potential clinical benefits associated with IC abciximab administration are warranted. © 2005 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)250-255
Number of pages6
JournalINTERNATIONAL JOURNAL OF CARDIOLOGY
Volume105
DOIs
Publication statusPublished - 2005

Keywords

  • Abciximab
  • Emergency Treatment
  • Percutaneous coronary interventions
  • Angina, Unstable
  • Antibodies, Monoclonal
  • Anticoagulants
  • Coronary Angiography
  • Female
  • Humans
  • Immunoglobulin Fab Fragments
  • Injections, Intra-Arterial
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Prospective Studies
  • Angioplasty, Balloon, Coronary
  • Acute coronary syndromes

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