Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy

Mariangela Palladino; Ilaria Gatto; Valentina Neri; Stefania Straino; Roy C. Smith; Marcy Silver; Eleonora Gaetani; Margherita Marcantoni; Igor Giarretta; Egidio Stigliano; Maurizio Capogrossi; Lynn Hlatky; Raffaele Landolfi; Roberto Pola

doi:10.1161/ATVBAHA.112.301172

Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy

Mariangela Palladino
, Ilaria Gatto
, Valentina Neri
, Stefania Straino
, Roy C. Smith
, Marcy Silver
, Eleonora Gaetani
, Margherita Marcantoni
, Igor Giarretta
, Egidio Stigliano
, Maurizio Capogrossi
, Lynn Hlatky
, Raffaele Landolfi
, Roberto Pola

IRCCS Istituto Dermopatico dell'Immacolata - Roma
Tufts University

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Dystrophin, the missing or defective protein in Duchenne muscular dystrophy, is expressed not only in muscle cells but also in vascular endothelial cells (ECs). In this study, we assessed the effects of dystrophin deficiency on the angiogenic capacities of ECs.

Original language	English
Pages (from-to)	2867-2876
Number of pages	10
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	33
DOIs	https://doi.org/10.1161/ATVBAHA.112.301172
Publication status	Published - 2013

Keywords

Animals
Apoptosis
Aspirin
Carcinoma, Lewis Lung
Caveolin 1
Cell Aging
Cell Movement
Cell Proliferation
Cells, Cultured
Coculture Techniques
Corneal Neovascularization
Cyclic GMP
Disease Models, Animal
Dystrophin
Endothelial Cells
Endothelium, Vascular
Ischemia
Mice
Mice, Inbred mdx
Muscular Dystrophy, Duchenne
Mutation
Myoblasts, Skeletal
Neovascularization, Pathologic
Neovascularization, Physiologic
Nitric Oxide
Nitric Oxide Synthase Type III
Time Factors
angiogenesis inhibitors
endothelium, vascular
muscle diseases, inflammatory
nitric oxide synthase type III

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10.1161/ATVBAHA.112.301172

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Palladino, M., Gatto, I., Neri, V., Straino, S., Smith, R. C., Silver, M., Gaetani, E., Marcantoni, M., Giarretta, I., Stigliano, E., Capogrossi, M., Hlatky, L., Landolfi, R., & Pola, R. (2013). Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy. Arteriosclerosis, Thrombosis, and Vascular Biology, 33, 2867-2876. https://doi.org/10.1161/ATVBAHA.112.301172

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abstract = "Dystrophin, the missing or defective protein in Duchenne muscular dystrophy, is expressed not only in muscle cells but also in vascular endothelial cells (ECs). In this study, we assessed the effects of dystrophin deficiency on the angiogenic capacities of ECs.",

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author = "Mariangela Palladino and Ilaria Gatto and Valentina Neri and Stefania Straino and Smith, \{Roy C.\} and Marcy Silver and Eleonora Gaetani and Margherita Marcantoni and Igor Giarretta and Egidio Stigliano and Maurizio Capogrossi and Lynn Hlatky and Raffaele Landolfi and Roberto Pola",

year = "2013",

doi = "10.1161/ATVBAHA.112.301172",

language = "English",

volume = "33",

pages = "2867--2876",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

publisher = "Lippincott Williams and Wilkins",

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Palladino, M, Gatto, I, Neri, V, Straino, S, Smith, RC, Silver, M, Gaetani, E, Marcantoni, M, Giarretta, I, Stigliano, E, Capogrossi, M, Hlatky, L, Landolfi, R & Pola, R 2013, 'Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 33, pp. 2867-2876. https://doi.org/10.1161/ATVBAHA.112.301172

TY - JOUR

T1 - Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy

AU - Palladino, Mariangela

AU - Gatto, Ilaria

AU - Neri, Valentina

AU - Straino, Stefania

AU - Smith, Roy C.

AU - Silver, Marcy

AU - Gaetani, Eleonora

AU - Marcantoni, Margherita

AU - Giarretta, Igor

AU - Stigliano, Egidio

AU - Capogrossi, Maurizio

AU - Hlatky, Lynn

AU - Landolfi, Raffaele

AU - Pola, Roberto

PY - 2013

Y1 - 2013

N2 - Dystrophin, the missing or defective protein in Duchenne muscular dystrophy, is expressed not only in muscle cells but also in vascular endothelial cells (ECs). In this study, we assessed the effects of dystrophin deficiency on the angiogenic capacities of ECs.

AB - Dystrophin, the missing or defective protein in Duchenne muscular dystrophy, is expressed not only in muscle cells but also in vascular endothelial cells (ECs). In this study, we assessed the effects of dystrophin deficiency on the angiogenic capacities of ECs.

KW - Animals

KW - Apoptosis

KW - Aspirin

KW - Carcinoma, Lewis Lung

KW - Caveolin 1

KW - Cell Aging

KW - Cell Movement

KW - Cell Proliferation

KW - Cells, Cultured

KW - Coculture Techniques

KW - Corneal Neovascularization

KW - Cyclic GMP

KW - Disease Models, Animal

KW - Dystrophin

KW - Endothelial Cells

KW - Endothelium, Vascular

KW - Ischemia

KW - Mice

KW - Mice, Inbred mdx

KW - Muscular Dystrophy, Duchenne

KW - Mutation

KW - Myoblasts, Skeletal

KW - Neovascularization, Pathologic

KW - Neovascularization, Physiologic

KW - Nitric Oxide

KW - Nitric Oxide Synthase Type III

KW - Time Factors

KW - angiogenesis inhibitors

KW - endothelium, vascular

KW - muscle diseases, inflammatory

KW - nitric oxide synthase type III

KW - Animals

KW - Apoptosis

KW - Aspirin

KW - Carcinoma, Lewis Lung

KW - Caveolin 1

KW - Cell Aging

KW - Cell Movement

KW - Cell Proliferation

KW - Cells, Cultured

KW - Coculture Techniques

KW - Corneal Neovascularization

KW - Cyclic GMP

KW - Disease Models, Animal

KW - Dystrophin

KW - Endothelial Cells

KW - Endothelium, Vascular

KW - Ischemia

KW - Mice

KW - Mice, Inbred mdx

KW - Muscular Dystrophy, Duchenne

KW - Mutation

KW - Myoblasts, Skeletal

KW - Neovascularization, Pathologic

KW - Neovascularization, Physiologic

KW - Nitric Oxide

KW - Nitric Oxide Synthase Type III

KW - Time Factors

KW - angiogenesis inhibitors

KW - endothelium, vascular

KW - muscle diseases, inflammatory

KW - nitric oxide synthase type III

UR - http://hdl.handle.net/10807/51194

U2 - 10.1161/ATVBAHA.112.301172

DO - 10.1161/ATVBAHA.112.301172

M3 - Article

SN - 1079-5642

VL - 33

SP - 2867

EP - 2876

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

ER -

Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy

Abstract

Keywords

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