Angiogenic impairment of the vascular endothelium: a novel mechanism and potential therapeutic target in muscular dystrophy

Eleonora Gaetani, Roberto Pola, Mariangela Palladino, Ilaria Gatto, Valentina Neri, Margherita Marcantoni, Igor Giarretta, Egidio Stigliano, Raffaele Landolfi, Stefania Straino, Roy C. Smith, Marcy Silver, Maurizio Capogrossi, Lynn Hlatky

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Dystrophin, the missing or defective protein in Duchenne muscular dystrophy, is expressed not only in muscle cells but also in vascular endothelial cells (ECs). In this study, we assessed the effects of dystrophin deficiency on the angiogenic capacities of ECs.
Original languageEnglish
Pages (from-to)2867-2876
Number of pages10
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume33
DOIs
Publication statusPublished - 2013

Keywords

  • Animals
  • Apoptosis
  • Aspirin
  • Carcinoma, Lewis Lung
  • Caveolin 1
  • Cell Aging
  • Cell Movement
  • Cell Proliferation
  • Cells, Cultured
  • Coculture Techniques
  • Corneal Neovascularization
  • Cyclic GMP
  • Disease Models, Animal
  • Dystrophin
  • Endothelial Cells
  • Endothelium, Vascular
  • Ischemia
  • Mice
  • Mice, Inbred mdx
  • Muscular Dystrophy, Duchenne
  • Mutation
  • Myoblasts, Skeletal
  • Neovascularization, Pathologic
  • Neovascularization, Physiologic
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Time Factors
  • angiogenesis inhibitors
  • endothelium, vascular
  • muscle diseases, inflammatory
  • nitric oxide synthase type III

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