Analysis of the arrhythmogenic substrate in human heart failure

Sara Partemi, Montserrat Batlle, Paola Berne, Antonio Berruezo, Begoña Campos, Luis Mont, Helena Riuró, Eulalia Roig, Felix Pérez-Villa, Jose Ortiz, Vincenzo Lorenzo Pascali, Antonio Oliva, Ramon Brugada, Josep Brugada

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The mechanism of sudden cardiac death in patients with heart failure (HF) is uncertain. Both electrical instability and structural remodelling could be factors that lead to fatal arrhythmias. We sought to analyse the expression of the sodium (SCN5A) and potassium (KCND3) channels as well as the fibrosis content in the ventricles of human HF and of non-diseased hearts under different post-mortem intervals.
Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalCardiovascular Pathology
Volume22
DOIs
Publication statusPublished - 2013

Keywords

  • arrhythmogenic substrate in human heart failure
  • sudden cardiac death

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