An integrated superhydrophobic-plasmonic biosensor for mid-infrared protein detection at the femtomole level

Gabriele Ciasca, Massimiliano Papi, Marco De Spirito, Adele De Ninno, Annamaria Gerardino, Eugenio Calandrini, Alessandro Nucara, Michele Ortolani, Luca Businaro, Leonetta Baldassarre

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

In this work we present an integrated biosensor that enables FTIR (Fourier Transform-Infrared) detection of analytes contained in diluted solutions. The fabricated nanosensor allows for the detection of proteins through the identification of the fine structure of their amide I and II bands, up to the nanomolar concentration range. We exploited two distinct effects to enhance the sensitivity: (i) the concentration effect due to the presence of the superhydrophobic surface that conveys molecules dispersed in solution directly inside the focus of a FTIR spectromicroscope; (ii) the plasmonic resonance of the nanoantenna array that provides electromagnetic field enhancement in the amide I and II spectral region (1500–1700 cm−1). We demonstrate the detection of ferritin in the nanomolar concentration range, a blood protein that is usually available in small amounts in typical blood samples.
Original languageEnglish
Pages (from-to)N/A-N/A
Number of pages8
JournalPhysical Chemistry Chemical Physics
Volume2015
DOIs
Publication statusPublished - 2015

Keywords

  • Surface Enhanced Spectroscopy

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