Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism

D. Seripa, M. G. Matera, R. P. D'Andrea, C. Gravina, Carlo Masullo, Antonio Daniele, A. Bizzarro, Alessandra Bizzarro, M. Rinaldi, P. Antuono, D. R. Wekstein, G. Dal Forno, V. M. Fazio, Vito Michele Fazio

Research output: Contribution to journalArticle

13 Citations (Scopus)


The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.
Original languageEnglish
Pages (from-to)1631-1633
Number of pages3
Publication statusPublished - 2004


  • Aged
  • Alzheimer Disease
  • Apolipoprotein E4
  • Apolipoproteins E
  • Case-Control Studies
  • DNA Mutational Analysis
  • European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Italy
  • Male
  • Polymorphism, Single Nucleotide
  • Risk
  • Risk Factors
  • Tissue Banks
  • Wisconsin
  • tau Proteins


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