Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR

D. Marzioni; T. Lorenzi; E. Altobelli; S. R. Giannubilo; F. Paolinelli; Chiara Tersigni; C. Crescimanno; V. Monsurrò; A. L. Tranquilli; Nicoletta Di Simone; M. Castellucci

doi:10.1016/j.placenta.2012.09.011

Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR

D. Marzioni, T. Lorenzi, E. Altobelli, S. R. Giannubilo, F. Paolinelli, Chiara Tersigni, C. Crescimanno, V. Monsurrò, A. L. Tranquilli, Nicoletta Di Simone, M. Castellucci

Università Cattolica del Sacro Cuore

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We evaluated the presence of HtrA1 in maternal plasma of normal pregnancies and of pregnancies complicated by preeclampsia (PE) without and with Intrauterine Growth Restriction (IUGR). We demonstrate that HtrA1 maternal plasma levels show significant different concentrations in first, second and third trimester of gestation and that HtrA1 concentration increases in maternal plasma of gestations complicated by PE with IUGR compared with control maternal plasma matched for gestational age. Based on these data high maternal plasma levels of HtrA1 could be considered as a possible marker of an occurring IUGR in preeclamptic women.

Original language	English
Pages (from-to)	1036-1038
Number of pages	3
Journal	Placenta
Volume	33
DOIs	https://doi.org/10.1016/j.placenta.2012.09.011
Publication status	Published - 2012

Keywords

HtrA1
Preeclampsia

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10.1016/j.placenta.2012.09.011

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title = "Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR",

abstract = "We evaluated the presence of HtrA1 in maternal plasma of normal pregnancies and of pregnancies complicated by preeclampsia (PE) without and with Intrauterine Growth Restriction (IUGR). We demonstrate that HtrA1 maternal plasma levels show significant different concentrations in first, second and third trimester of gestation and that HtrA1 concentration increases in maternal plasma of gestations complicated by PE with IUGR compared with control maternal plasma matched for gestational age. Based on these data high maternal plasma levels of HtrA1 could be considered as a possible marker of an occurring IUGR in preeclamptic women.",

keywords = "HtrA1, Preeclampsia, HtrA1, Preeclampsia",

author = "D. Marzioni and T. Lorenzi and E. Altobelli and Giannubilo, {S. R.} and F. Paolinelli and Chiara Tersigni and C. Crescimanno and V. Monsurr{\`o} and Tranquilli, {A. L.} and {Di Simone}, Nicoletta and M. Castellucci",

year = "2012",

doi = "10.1016/j.placenta.2012.09.011",

language = "English",

volume = "33",

pages = "1036--1038",

journal = "Placenta",

issn = "0143-4004",

publisher = "W.B. Saunders Ltd",

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TY - JOUR

T1 - Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR

AU - Marzioni, D.

AU - Lorenzi, T.

AU - Altobelli, E.

AU - Giannubilo, S. R.

AU - Paolinelli, F.

AU - Tersigni, Chiara

AU - Crescimanno, C.

AU - Monsurrò, V.

AU - Tranquilli, A. L.

AU - Di Simone, Nicoletta

AU - Castellucci, M.

PY - 2012

Y1 - 2012

N2 - We evaluated the presence of HtrA1 in maternal plasma of normal pregnancies and of pregnancies complicated by preeclampsia (PE) without and with Intrauterine Growth Restriction (IUGR). We demonstrate that HtrA1 maternal plasma levels show significant different concentrations in first, second and third trimester of gestation and that HtrA1 concentration increases in maternal plasma of gestations complicated by PE with IUGR compared with control maternal plasma matched for gestational age. Based on these data high maternal plasma levels of HtrA1 could be considered as a possible marker of an occurring IUGR in preeclamptic women.

AB - We evaluated the presence of HtrA1 in maternal plasma of normal pregnancies and of pregnancies complicated by preeclampsia (PE) without and with Intrauterine Growth Restriction (IUGR). We demonstrate that HtrA1 maternal plasma levels show significant different concentrations in first, second and third trimester of gestation and that HtrA1 concentration increases in maternal plasma of gestations complicated by PE with IUGR compared with control maternal plasma matched for gestational age. Based on these data high maternal plasma levels of HtrA1 could be considered as a possible marker of an occurring IUGR in preeclamptic women.

KW - HtrA1

KW - Preeclampsia

KW - HtrA1

KW - Preeclampsia

UR - http://hdl.handle.net/10807/102376

U2 - 10.1016/j.placenta.2012.09.011

DO - 10.1016/j.placenta.2012.09.011

M3 - Article

SN - 0143-4004

VL - 33

SP - 1036

EP - 1038

JO - Placenta

JF - Placenta

ER -

Alterations of maternal plasma HTRA1 level in preeclampsia complicated by IUGR

Abstract

Keywords

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