Alpha-1-antitrypsin protease inhibitor SZ phenotype and liver cirrhosis

Antonella Coli, Giulio Bigotti

Research output: Contribution to journalArticle

1 Citation (Scopus)


In the light of recent findings concerning the importance of intermediate alpha 1-antitrypsin deficiency in the development of chronic liver disease and of hepatocellular carcinoma, we report the case of a 56-year-old woman affected by cirrhosis with significant features of liver cell dysplasia associated with intermediate alpha 1-antitrypsin deficiency (protease inhibitor SZ phenotype). In our paper we emphasize the importance of a precocious diagnosis and identification of individuals carrying the Z allele, also heterozygous.
Original languageEnglish
Pages (from-to)54-60
Number of pages7
Publication statusPublished - 1989


  • Female
  • Humans
  • Liver Cirrhosis
  • Middle Aged
  • Phenotype
  • alpha 1-Antitrypsin
  • alpha 1-Antitrypsin Deficiency


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