Allosterich properties of hemoglobin and the plasma membrane of the erythrocyte: New insights in Gas Transport and Metabolic Modulation

Maria Cristina De Rosa, Cristiana Carelli Alinovi, Andrea Russo, Bruno Giardina, A. Galtieri

Research output: Contribution to journalArticle

Abstract

Within the red blood cell the hemoglobin molecule is subjected to modulation mechanisms, namely homo- and heterotropic interactions, which optimize its functional behavior to the specific physiological requirements. At the cellular level, these modulation mechanisms are utilized to perform a number of other functions that are not minor with respect to the basic function of oxygen transport. Here we report some key examples concerning: (i) the interaction of hemoglobin with band 3 and its influence on glucose metabolism; (ii) the role of the ligand-linked quaternary transition of hemoglobin in the control of "NO bioactivity" and of gas diffusion; (iii) the interaction of plasma membrane with the various oxidative derivatives of the hemoglobin molecule
Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalIUBMB Life
Publication statusPublished - 2008

Keywords

  • 2,3-DPG
  • band 3
  • nitric oxide
  • red blood cells

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