All-cause mortality associated with atypical and conventional antipsychotics among nursing home residents with dementia: a retrospective cohort study

Rosa Liperoti, Graziano Onder, Roberto Bernabei, Giovanni Gambassi, Francesco Luigi Landi, Kl Lapane, V Mor

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

A recent meta-analysis has indicated that, in patients with dementia, the use of atypical antipsychotics is associated with an excess mortality. Later observational studies have suggested that conventional antipsychotics may pose an even greater risk of death. None of these studies could evaluate the risk associated with single antipsychotics nor could they provide any conclusive evidence concerning the risk among nursing home residents. We conducted a retrospective cohort study to compare the risk of death associated with atypical and conventional antipsychotics in a large population of nursing home residents with dementia.
Original languageEnglish
Pages (from-to)1340-1347
Number of pages8
JournalJournal of Clinical Psychiatry
Volume70
DOIs
Publication statusPublished - 2009

Keywords

  • Aged, 80 and over
  • Alzheimer Disease
  • Antipsychotic Agents
  • Cardiovascular Diseases
  • Cause of Death
  • Cerebrovascular Disorders
  • Cohort Studies
  • Comorbidity
  • Dementia
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Nursing Homes
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis
  • Time Factors
  • United States

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