Advanced colon cancer: staging and prognosis by CEA test

Carlo Antonio Barone, Antonio Astone, Alessandra Cassano, C Garufi, Antonio Grieco, Noviello, E Ricevuto, C Albanese, Giovanni Gambassi

Research output: Contribution to journalArticle

9 Citations (Scopus)


The carcinoembryonic antigen (CEA) test was studied in 54 patients with advanced stages of colon cancer which was treated with high doses of folinic acid + fluorouracil. The CEA test correlates evaluated included: prognostic value, performance status, metastatic pattern, histologic grading, predictive value for response to chemotherapy, and value differences in cases with partial response to therapy. CEA levels less than 5 ng/ml corresponded to a greater survival time than did levels greater than 5 ng/ml. A correlation of CEA with performance status and with metastatic pattern was demonstrated. A progressive increase in average CEA values corresponded to increases in neoplastic mass. Although CEA levels were not found to be an index for predicting the response to chemotherapy, there was a significant different between pre- and posttreatment levels for partial response. The results suggest that CEA offers an additional criterion for evaluating the response of colon cancer to chemotherapy and it also has a role in the staging of advanced disease.
Original languageEnglish
Pages (from-to)128-132
Number of pages5
Publication statusPublished - 1990


  • Adult
  • Aged
  • Carcinoembryonic Antigen
  • Colonic Neoplasms
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Prognosis
  • Survival Rate


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