Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

Luca Giraldi; Jovana Stojanovic; Dario Arzani; Roberto Persiani; Jinfu Hu; Kenneth C. Johnson; Zuo-Feng Zhang; Monica Ferraroni; Domenico Palli; Guo-Pei Yu; Carlo La Vecchia; Claudio Pelucchi; Nuno Lunet; Ana Ferro; Reza Malekzadeh; Joshua Muscat; David Zaridze; Dmitry Maximovich; Nuria Aragones; Vicente Martin; Jesùs Vioque; Eva M. Navarrete-Munoz; Mohammadreza Pakseresht; Eva Negri; Matteo Rota; Farhad Pourfarzi; Lina Mu; Robert C. Kurtz; Areti Lagiou; Pagona Lagiou; Roberta Pastorino; Stefania Boccia

doi:10.1097/CEJ.0000000000000613

Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente MartinJesùs Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia

Research output: Contribution to journal › Article

Abstract

BackgroundThe association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium. MethodsData from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables. ResultsA total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20). ConclusionOur study does not support a strong and consistent association between adult height and gastric cancer.

Original language	English
Pages (from-to)	215-221
Number of pages	7
Journal	European Journal of Cancer Prevention
Volume	32
DOIs	https://doi.org/10.1097/CEJ.0000000000000613
Publication status	Published - 2023

Keywords

adult height
pooled-analysis
gastric cancer
cancer risk factor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/CEJ.0000000000000613

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Giraldi, L., Stojanovic, J., Arzani, D., Persiani, R., Hu, J., Johnson, K. C., Zhang, Z.-F., Ferraroni, M., Palli, D., Yu, G.-P., La Vecchia, C., Pelucchi, C., Lunet, N., Ferro, A., Malekzadeh, R., Muscat, J., Zaridze, D., Maximovich, D., Aragones, N., ... Boccia, S. (2023). Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project. European Journal of Cancer Prevention, 32, 215-221. https://doi.org/10.1097/CEJ.0000000000000613

@article{2c4561f154c84337b6588981c18568ae,

title = "Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project",

abstract = "BackgroundThe association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium. MethodsData from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables. ResultsA total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20). ConclusionOur study does not support a strong and consistent association between adult height and gastric cancer.",

keywords = "adult height, pooled-analysis, gastric cancer, cancer risk factor, adult height, pooled-analysis, gastric cancer, cancer risk factor",

author = "Luca Giraldi and Jovana Stojanovic and Dario Arzani and Roberto Persiani and Jinfu Hu and Johnson, {Kenneth C.} and Zuo-Feng Zhang and Monica Ferraroni and Domenico Palli and Guo-Pei Yu and {La Vecchia}, Carlo and Claudio Pelucchi and Nuno Lunet and Ana Ferro and Reza Malekzadeh and Joshua Muscat and David Zaridze and Dmitry Maximovich and Nuria Aragones and Vicente Martin and Jes{\`u}s Vioque and Navarrete-Munoz, {Eva M.} and Mohammadreza Pakseresht and Eva Negri and Matteo Rota and Farhad Pourfarzi and Lina Mu and Kurtz, {Robert C.} and Areti Lagiou and Pagona Lagiou and Roberta Pastorino and Stefania Boccia",

year = "2023",

doi = "10.1097/CEJ.0000000000000613",

language = "English",

volume = "32",

pages = "215--221",

journal = "European Journal of Cancer Prevention",

issn = "0959-8278",

publisher = "Lippincott Williams and Wilkins",

}

Giraldi, L, Stojanovic, J, Arzani, D, Persiani, R, Hu, J, Johnson, KC, Zhang, Z-F, Ferraroni, M, Palli, D, Yu, G-P, La Vecchia, C, Pelucchi, C, Lunet, N, Ferro, A, Malekzadeh, R, Muscat, J, Zaridze, D, Maximovich, D, Aragones, N, Martin, V, Vioque, J, Navarrete-Munoz, EM, Pakseresht, M, Negri, E, Rota, M, Pourfarzi, F, Mu, L, Kurtz, RC, Lagiou, A, Lagiou, P, Pastorino, R & Boccia, S 2023, 'Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project', European Journal of Cancer Prevention, vol. 32, pp. 215-221. https://doi.org/10.1097/CEJ.0000000000000613

TY - JOUR

T1 - Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

AU - Giraldi, Luca

AU - Stojanovic, Jovana

AU - Arzani, Dario

AU - Persiani, Roberto

AU - Hu, Jinfu

AU - Johnson, Kenneth C.

AU - Zhang, Zuo-Feng

AU - Ferraroni, Monica

AU - Palli, Domenico

AU - Yu, Guo-Pei

AU - La Vecchia, Carlo

AU - Pelucchi, Claudio

AU - Lunet, Nuno

AU - Ferro, Ana

AU - Malekzadeh, Reza

AU - Muscat, Joshua

AU - Zaridze, David

AU - Maximovich, Dmitry

AU - Aragones, Nuria

AU - Martin, Vicente

AU - Vioque, Jesùs

AU - Navarrete-Munoz, Eva M.

AU - Pakseresht, Mohammadreza

AU - Negri, Eva

AU - Rota, Matteo

AU - Pourfarzi, Farhad

AU - Mu, Lina

AU - Kurtz, Robert C.

AU - Lagiou, Areti

AU - Lagiou, Pagona

AU - Pastorino, Roberta

AU - Boccia, Stefania

PY - 2023

Y1 - 2023

N2 - BackgroundThe association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium. MethodsData from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables. ResultsA total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20). ConclusionOur study does not support a strong and consistent association between adult height and gastric cancer.

AB - BackgroundThe association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium. MethodsData from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables. ResultsA total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20). ConclusionOur study does not support a strong and consistent association between adult height and gastric cancer.

KW - adult height

KW - pooled-analysis

KW - gastric cancer

KW - cancer risk factor

KW - adult height

KW - pooled-analysis

KW - gastric cancer

KW - cancer risk factor

UR - http://hdl.handle.net/10807/297859

U2 - 10.1097/CEJ.0000000000000613

DO - 10.1097/CEJ.0000000000000613

M3 - Article

SN - 0959-8278

VL - 32

SP - 215

EP - 221

JO - European Journal of Cancer Prevention

JF - European Journal of Cancer Prevention

ER -

Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

Abstract

Keywords

UN SDGs

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