Adult granulosa cell tumor in pregnancy: A new case and a review of the literature

Sofia Guidi, Vincenzo Berghella, Giovanni Scambia, Anna Fagotti, Antonello Vidiri, Stefano Restaino, Giuseppe Vizzielli, Frediano Inzani, Anna Franca Cavaliere

Research output: Contribution to journalArticle


Granulosa cell tumors are rare ovarian tumors that can arise during pregnancy. We present a new case of recurrent adult granulosa cell tumor (AGCT) in pregnancy and a systematic review of the literature. The new case described is a 41-year-old woman G5P1122 with a prior history of AGCT that was referred to our center at 29 weeks because of a symptomatic abdominal mass, compatible with a possible recurrence of AGCT. At 36 + 3 weeks, she underwent a cesarean delivery for preterm labor and a total hysterectomy with a radical surgical staging. A healthy female infant was delivered. The patient received a platinum-based chemotherapy, with a 26-month follow-up negative for recurrence. Analyzing our case with the four identified by the literature review, three were recurrent and two were primary AGCT. Only one required surgery for AGCT at 15 weeks, while another underwent chemotherapy in pregnancy. In the other three cases, surgery for AGCT was done at the time of cesarean delivery. There were three cases of preterm delivery. All five pregnancies resulted in the birth of live babies with weight adequate for gestational age. In conclusion, AGCT diagnosed in pregnancy is rare, reported in only five cases. All gave birth to live babies in the third trimester, and maternal outcome at up to 18 months showed no recurrence.
Original languageEnglish
Pages (from-to)1455-1463
Number of pages9
Publication statusPublished - 2021


  • Fetal outcome
  • Granulosa cell tumor
  • Gynecology
  • Maternal outcome
  • Ovarian cancer
  • Pregnancy
  • Recurrence


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