Adipose and muscle tissue profile of CD36 transcripts in obese subjects highlights the role of CD36 in fatty acid homeostasis and insulin resistance

Caterina Conte, Terri A. Pietka, Timothy Schappe, Elisa Fabbrini, Bruce W. Patterson, Samuel Klein, Nada A. Abumrad, Latisha Love-Gregory

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Fatty acid (FA) metabolism is tightly regulated across several tissues and impacts insulin sensitivity. CD36 facilitates cellular FA uptake, and CD36 genetic variants associate with lipid abnormalities and susceptibility to metabolic syndrome. The objective of this study was to gain insight regarding the in vivo metabolic influence of muscle and adipose tissue CD36. For this, we determined the relationships between CD36 alternative transcripts, which can reflect tissue-specific CD36 regulation, and measures of FA metabolism and insulin resistance.
Original languageEnglish
Pages (from-to)1990-1997
Number of pages8
JournalDiabetes Care
Volume37
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • adipose tissue
  • cd36

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