-Adhesion molecules in inflammatory bowel disease: therapeutic implications for gut inflammation

Alessandro Armuzzi, Alfredo Papa, Antonio Gasbarrini, Silvio Danese, Stefano Semeraro, M Marini, I Roberto

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Abstract Mucosal endothelium has become one of the major areas of investigation in gut inflammation. It is now well recognised that it plays an active role in the pathogenesis of both forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis, since endothelial cells regulate mucosal immune homeostasis, acting as "gatekeepers", controlling leukocyte accumulation in the interstitial compartment. This process is mediated by leukocyte-endothelial adhesion molecules. This paper reviews the major molecules that mediate leukocyte-endothelial interactions, and summarises the results of the most recent clinical trials targeting adhesion molecules in inflammatory bowel diseas
Original languageEnglish
Pages (from-to)811-818
Number of pages8
JournalDIGESTIVE AND LIVER DISEASE
Publication statusPublished - 2005

Keywords

  • Adhesion molecules

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