Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

Daniela Pedicino; Giovanna Liuzzo; Francesco Trotta; Ada Francesca Giglio; Simona Giubilato; Francesca Martini; Francesco Zaccardi; Giuseppe Scavone; Marco Previtero; Gianluca Massaro; Pio Cialdella; Maria Teresa Cardillo; Dario Pitocco; Giovanni Ghirlanda; Filippo Crea

doi:10.1155/2013/184258

Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

Daniela Pedicino
, Giovanna Liuzzo
, Francesco Trotta
, Ada Francesca Giglio
, Simona Giubilato
, Francesca Martini
, Francesco Zaccardi
, Giuseppe Scavone
, Marco Previtero
, Gianluca Massaro
, Pio Cialdella
, Maria Teresa Cardillo
, Dario Pitocco
, Giovanni Ghirlanda
, Filippo Crea

Research output: Contribution to journal › Article

35 Citations (Scopus)

Abstract

Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Journal of Diabetes Research
Volume	2013
DOIs	https://doi.org/10.1155/2013/184258
Publication status	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adaptive Immunity
Adult
Aged
Cardiovascular Diseases
Cell Line
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Female
Humans
Inflammation
Insulin Resistance
Insulin-Secreting Cells
Male
Middle Aged
T-Lymphocyte Subsets

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10.1155/2013/184258

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Pedicino, D., Liuzzo, G., Trotta, F., Giglio, A. F., Giubilato, S., Martini, F., Zaccardi, F., Scavone, G., Previtero, M., Massaro, G., Cialdella, P., Cardillo, M. T., Pitocco, D., Ghirlanda, G., & Crea, F. (2013). Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus. Journal of Diabetes Research, 2013, N/A-N/A. https://doi.org/10.1155/2013/184258

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title = "Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus",

abstract = "Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.",

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author = "Daniela Pedicino and Giovanna Liuzzo and Francesco Trotta and Giglio, \{Ada Francesca\} and Simona Giubilato and Francesca Martini and Francesco Zaccardi and Giuseppe Scavone and Marco Previtero and Gianluca Massaro and Pio Cialdella and Cardillo, \{Maria Teresa\} and Dario Pitocco and Giovanni Ghirlanda and Filippo Crea",

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doi = "10.1155/2013/184258",

language = "English",

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Pedicino, D, Liuzzo, G, Trotta, F, Giglio, AF, Giubilato, S, Martini, F, Zaccardi, F, Scavone, G, Previtero, M, Massaro, G, Cialdella, P, Cardillo, MT, Pitocco, D, Ghirlanda, G & Crea, F 2013, 'Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus', Journal of Diabetes Research, vol. 2013, pp. N/A-N/A. https://doi.org/10.1155/2013/184258

TY - JOUR

T1 - Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

AU - Pedicino, Daniela

AU - Liuzzo, Giovanna

AU - Trotta, Francesco

AU - Giglio, Ada Francesca

AU - Giubilato, Simona

AU - Martini, Francesca

AU - Zaccardi, Francesco

AU - Scavone, Giuseppe

AU - Previtero, Marco

AU - Massaro, Gianluca

AU - Cialdella, Pio

AU - Cardillo, Maria Teresa

AU - Pitocco, Dario

AU - Ghirlanda, Giovanni

AU - Crea, Filippo

PY - 2013

Y1 - 2013

N2 - Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

AB - Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

KW - Adaptive Immunity

KW - Adult

KW - Aged

KW - Cardiovascular Diseases

KW - Cell Line

KW - Diabetes Mellitus, Type 1

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Inflammation

KW - Insulin Resistance

KW - Insulin-Secreting Cells

KW - Male

KW - Middle Aged

KW - T-Lymphocyte Subsets

KW - Adaptive Immunity

KW - Adult

KW - Aged

KW - Cardiovascular Diseases

KW - Cell Line

KW - Diabetes Mellitus, Type 1

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Inflammation

KW - Insulin Resistance

KW - Insulin-Secreting Cells

KW - Male

KW - Middle Aged

KW - T-Lymphocyte Subsets

UR - http://hdl.handle.net/10807/52657

U2 - 10.1155/2013/184258

DO - 10.1155/2013/184258

M3 - Article

SN - 2314-6745

VL - 2013

SP - N/A-N/A

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

ER -

Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

Abstract

UN SDGs

Keywords

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