Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

Daniela Pedicino; Giovanna Liuzzo; Francesco Trotta; Ada Francesca Giglio; Simona Giubilato; Francesca Martini; Francesco Zaccardi; Giuseppe Scavone; Marco Previtero; Gianluca Massaro; Pio Cialdella; Maria Teresa Cardillo; Dario Pitocco; Giovanni Ghirlanda; Filippo Crea

doi:10.1155/2013/184258

Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

Daniela Pedicino, Giovanna Liuzzo, Francesco Trotta, Ada Francesca Giglio, Simona Giubilato, Francesca Martini, Francesco Zaccardi, Giuseppe Scavone, Marco Previtero, Gianluca Massaro, Pio Cialdella, Maria Teresa Cardillo, Dario Pitocco, Giovanni Ghirlanda, Filippo Crea

Research output: Contribution to journal › Article

35 Citations (Scopus)

Abstract

Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Journal of Diabetes Research
Volume	2013
DOIs	https://doi.org/10.1155/2013/184258
Publication status	Published - 2013

Keywords

Adaptive Immunity
Adult
Aged
Cardiovascular Diseases
Cell Line
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Female
Humans
Inflammation
Insulin Resistance
Insulin-Secreting Cells
Male
Middle Aged
T-Lymphocyte Subsets

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1155/2013/184258

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Pedicino, D., Liuzzo, G., Trotta, F., Giglio, A. F., Giubilato, S., Martini, F., Zaccardi, F., Scavone, G., Previtero, M., Massaro, G., Cialdella, P., Cardillo, M. T., Pitocco, D., Ghirlanda, G., & Crea, F. (2013). Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus. Journal of Diabetes Research, 2013, N/A-N/A. https://doi.org/10.1155/2013/184258

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title = "Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus",

abstract = "Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.",

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author = "Daniela Pedicino and Giovanna Liuzzo and Francesco Trotta and Giglio, {Ada Francesca} and Simona Giubilato and Francesca Martini and Francesco Zaccardi and Giuseppe Scavone and Marco Previtero and Gianluca Massaro and Pio Cialdella and Cardillo, {Maria Teresa} and Dario Pitocco and Giovanni Ghirlanda and Filippo Crea",

year = "2013",

doi = "10.1155/2013/184258",

language = "English",

volume = "2013",

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publisher = "John Wiley and Sons Ltd",

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Pedicino, D, Liuzzo, G, Trotta, F, Giglio, AF, Giubilato, S, Martini, F, Zaccardi, F, Scavone, G, Previtero, M, Massaro, G, Cialdella, P, Cardillo, MT, Pitocco, D, Ghirlanda, G & Crea, F 2013, 'Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus', Journal of Diabetes Research, vol. 2013, pp. N/A-N/A. https://doi.org/10.1155/2013/184258

TY - JOUR

T1 - Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

AU - Pedicino, Daniela

AU - Liuzzo, Giovanna

AU - Trotta, Francesco

AU - Giglio, Ada Francesca

AU - Giubilato, Simona

AU - Martini, Francesca

AU - Zaccardi, Francesco

AU - Scavone, Giuseppe

AU - Previtero, Marco

AU - Massaro, Gianluca

AU - Cialdella, Pio

AU - Cardillo, Maria Teresa

AU - Pitocco, Dario

AU - Ghirlanda, Giovanni

AU - Crea, Filippo

PY - 2013

Y1 - 2013

N2 - Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

AB - Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

KW - Adaptive Immunity

KW - Adult

KW - Aged

KW - Cardiovascular Diseases

KW - Cell Line

KW - Diabetes Mellitus, Type 1

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Inflammation

KW - Insulin Resistance

KW - Insulin-Secreting Cells

KW - Male

KW - Middle Aged

KW - T-Lymphocyte Subsets

KW - Adaptive Immunity

KW - Adult

KW - Aged

KW - Cardiovascular Diseases

KW - Cell Line

KW - Diabetes Mellitus, Type 1

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Inflammation

KW - Insulin Resistance

KW - Insulin-Secreting Cells

KW - Male

KW - Middle Aged

KW - T-Lymphocyte Subsets

UR - http://hdl.handle.net/10807/52657

U2 - 10.1155/2013/184258

DO - 10.1155/2013/184258

M3 - Article

SN - 2314-6745

VL - 2013

SP - N/A-N/A

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

ER -

Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

Abstract

Keywords

UN SDGs

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