Adaptive Immunity Dysregulation in Acute Coronary Syndromes: From Cellular and Molecular Basis to Clinical Implications

[Autom. eng. transl.] The early outcome of acute coronary syndrome (ACS) has significantly improved in the last decade, cardiovascular diseases still represent the main cause of morbidity and mortality worldwide. This is mainly due to the recurrence of ACS leading to the pandemic of heart failure and sudden cardiac death, thus calling for a reappraisal of the mechanisms responsible for coronary instability. This review discusses recent advances in our understanding of how adaptive immunity contributes to the pathogenesis of ACS and the clinical implications that arise from these new pathogenic concepts.