Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management

John Donald Marra; Filippo Frioni; Gessica Minnella; Monica Rossi; Tanja Malara; Silvia Bellesi; Elena Maiolo; Daniela Orteschi; Eugenio Galli; Andrea Bacigalupo; Livio Pagano; Simona Sica; Gina Zini Tanzi; Patrizia Chiusolo

doi:10.1007/s00277-023-05561-3

Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management

John Donald Marra, Filippo Frioni, Gessica Minnella, Monica Rossi, Tanja Malara, Silvia Bellesi, Elena Maiolo, Daniela Orteschi, Eugenio Galli, Andrea Bacigalupo, Livio Pagano, Simona Sica, Gina Zini Tanzi, Patrizia Chiusolo

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Abstract

A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient’s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Annals of Hematology
Volume	103
DOIs	https://doi.org/10.1007/s00277-023-05561-3
Publication status	Published - 2024

Keywords

Classification
BCR-ABL
TP53
Acute erythroid leukemia

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10.1007/s00277-023-05561-3

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Marra, J. D., Frioni, F., Minnella, G., Rossi, M., Malara, T., Bellesi, S., Maiolo, E., Orteschi, D., Galli, E., Bacigalupo, A., Pagano, L., Sica, S., Zini Tanzi, G., & Chiusolo, P. (2024). Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management. Annals of Hematology, 103, N/A-N/A. https://doi.org/10.1007/s00277-023-05561-3

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title = "Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management",

abstract = "A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient{\textquoteright}s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.",

keywords = "Classification, BCR-ABL, TP53, Acute erythroid leukemia, Classification, BCR-ABL, TP53, Acute erythroid leukemia",

author = "Marra, {John Donald} and Filippo Frioni and Gessica Minnella and Monica Rossi and Tanja Malara and Silvia Bellesi and Elena Maiolo and Daniela Orteschi and Eugenio Galli and Andrea Bacigalupo and Livio Pagano and Simona Sica and {Zini Tanzi}, Gina and Patrizia Chiusolo",

year = "2024",

doi = "10.1007/s00277-023-05561-3",

language = "English",

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TY - JOUR

T1 - Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management

AU - Marra, John Donald

AU - Frioni, Filippo

AU - Minnella, Gessica

AU - Rossi, Monica

AU - Malara, Tanja

AU - Bellesi, Silvia

AU - Maiolo, Elena

AU - Orteschi, Daniela

AU - Galli, Eugenio

AU - Bacigalupo, Andrea

AU - Pagano, Livio

AU - Sica, Simona

AU - Zini Tanzi, Gina

AU - Chiusolo, Patrizia

PY - 2024

Y1 - 2024

N2 - A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient’s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.

AB - A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient’s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.

KW - Classification

KW - BCR-ABL

KW - TP53

KW - Acute erythroid leukemia

KW - Classification

KW - BCR-ABL

KW - TP53

KW - Acute erythroid leukemia

UR - http://hdl.handle.net/10807/296757

U2 - 10.1007/s00277-023-05561-3

DO - 10.1007/s00277-023-05561-3

M3 - Article

SN - 1432-0584

VL - 103

SP - N/A-N/A

JO - Annals of Hematology

JF - Annals of Hematology

ER -

Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management

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Keywords

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