Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial

Andrew P Cope; Marianna Jasenecova; Joana C Vasconcelos; Andrew Filer; Karim Raza; Sumera Qureshi; Maria Antonietta D'Agostino; Iain B Mcinnes; John D Isaacs; Arthur G Pratt; Benjamin A Fisher; Christopher D Buckley; Paul Emery; Pauline Ho; Maya H Buch; Coziana Ciurtin; Dirkjan Van Schaardenburg; Thomas Huizinga; René Toes; Evangelos Georgiou; Joanna Kelly; Caroline Murphy; A Toby Prevost; Sam Norton; Heidi Lempp; Maria Opena; Sujith Subesinghe; Toby Garrood; Bina Menon; Nora Ng; Karen Douglas; Christos Koutsianas; Faye Cooles; Marie Falahee; Irene Echavez-Naguicnic; Anurag Bharadwaj; Michael Villaruel; Ira Pande; David Collins; Suzannah Pegler; Sabrina Raizada; Stefan Siebert; George Fragoulis; Jesusa Guinto; James Galloway; Andrew Rutherford; Theresa Barnes; Helen Jeffrey; Yusuf Patel; Michael Batley; Brendan O'Reilly; Srivinisan Venkatachalam; Thomas Sheeran; Claire Gorman; Piero Reynolds; Asad Khan; Nicola Gullick; Siwalik Banerjee; Kulveer Mankia; Deepak Jordan; Jane Rowlands; Mirian Starmans-Kool; James Taylor; Pradip Nandi; Ilfita Sahbudin; Mark Maybury; Samantha Hider; Ann Barcroft; Jeremy Mcnally; Jo Kitchen; Muhammad Nisar; Vanessa Quick

doi:10.1016/s0140-6736(23)02649-1

Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial

Andrew P Cope, Marianna Jasenecova, Joana C Vasconcelos, Andrew Filer, Karim Raza, Sumera Qureshi, Maria Antonietta D'Agostino, Iain B Mcinnes, John D Isaacs, Arthur G Pratt, Benjamin A Fisher, Christopher D Buckley, Paul Emery, Pauline Ho, Maya H Buch, Coziana Ciurtin, Dirkjan Van Schaardenburg, Thomas Huizinga, René Toes, Evangelos GeorgiouJoanna Kelly, Caroline Murphy, A Toby Prevost, Sam Norton, Heidi Lempp, Maria Opena, Sujith Subesinghe, Toby Garrood, Bina Menon, Nora Ng, Karen Douglas, Christos Koutsianas, Faye Cooles, Marie Falahee, Irene Echavez-Naguicnic, Anurag Bharadwaj, Michael Villaruel, Ira Pande, David Collins, Suzannah Pegler, Sabrina Raizada, Stefan Siebert, George Fragoulis, Jesusa Guinto, James Galloway, Andrew Rutherford, Theresa Barnes, Helen Jeffrey, Yusuf Patel, Michael Batley, Brendan O'Reilly, Srivinisan Venkatachalam, Thomas Sheeran, Claire Gorman, Piero Reynolds, Asad Khan, Nicola Gullick, Siwalik Banerjee, Kulveer Mankia, Deepak Jordan, Jane Rowlands, Mirian Starmans-Kool, James Taylor, Pradip Nandi, Ilfita Sahbudin, Mark Maybury, Samantha Hider, Ann Barcroft, Jeremy Mcnally, Jo Kitchen, Muhammad Nisar, Vanessa Quick

Research output: Contribution to journal › Article

Original language	English
Pages (from-to)	838-849
Number of pages	12
Journal	The Lancet
Volume	403
DOIs	https://doi.org/10.1016/s0140-6736(23)02649-1
Publication status	Published - 2024

Keywords

APIPPRA
Abatacept
phase 2b clinical trial
rheumatoid arthritis

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10.1016/s0140-6736(23)02649-1

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Cope, A. P., Jasenecova, M., Vasconcelos, J. C., Filer, A., Raza, K., Qureshi, S., D'Agostino, M. A., Mcinnes, I. B., Isaacs, J. D., Pratt, A. G., Fisher, B. A., Buckley, C. D., Emery, P., Ho, P., Buch, M. H., Ciurtin, C., Van Schaardenburg, D., Huizinga, T., Toes, R., ... Quick, V. (2024). Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial. The Lancet, 403, 838-849. https://doi.org/10.1016/s0140-6736(23)02649-1

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title = "Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial",

keywords = "APIPPRA, Abatacept, phase 2b clinical trial, rheumatoid arthritis, APIPPRA, Abatacept, phase 2b clinical trial, rheumatoid arthritis",

author = "Cope, {Andrew P} and Marianna Jasenecova and Vasconcelos, {Joana C} and Andrew Filer and Karim Raza and Sumera Qureshi and D'Agostino, {Maria Antonietta} and Mcinnes, {Iain B} and Isaacs, {John D} and Pratt, {Arthur G} and Fisher, {Benjamin A} and Buckley, {Christopher D} and Paul Emery and Pauline Ho and Buch, {Maya H} and Coziana Ciurtin and {Van Schaardenburg}, Dirkjan and Thomas Huizinga and Ren{\'e} Toes and Evangelos Georgiou and Joanna Kelly and Caroline Murphy and Prevost, {A Toby} and Sam Norton and Heidi Lempp and Maria Opena and Sujith Subesinghe and Toby Garrood and Bina Menon and Nora Ng and Karen Douglas and Christos Koutsianas and Faye Cooles and Marie Falahee and Irene Echavez-Naguicnic and Anurag Bharadwaj and Michael Villaruel and Ira Pande and David Collins and Suzannah Pegler and Sabrina Raizada and Stefan Siebert and George Fragoulis and Jesusa Guinto and James Galloway and Andrew Rutherford and Theresa Barnes and Helen Jeffrey and Yusuf Patel and Michael Batley and Brendan O'Reilly and Srivinisan Venkatachalam and Thomas Sheeran and Claire Gorman and Piero Reynolds and Asad Khan and Nicola Gullick and Siwalik Banerjee and Kulveer Mankia and Deepak Jordan and Jane Rowlands and Mirian Starmans-Kool and James Taylor and Pradip Nandi and Ilfita Sahbudin and Mark Maybury and Samantha Hider and Ann Barcroft and Jeremy Mcnally and Jo Kitchen and Muhammad Nisar and Vanessa Quick",

year = "2024",

doi = "10.1016/s0140-6736(23)02649-1",

language = "English",

volume = "403",

pages = "838--849",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

}

Cope, AP, Jasenecova, M, Vasconcelos, JC, Filer, A, Raza, K, Qureshi, S, D'Agostino, MA, Mcinnes, IB, Isaacs, JD, Pratt, AG, Fisher, BA, Buckley, CD, Emery, P, Ho, P, Buch, MH, Ciurtin, C, Van Schaardenburg, D, Huizinga, T, Toes, R, Georgiou, E, Kelly, J, Murphy, C, Prevost, AT, Norton, S, Lempp, H, Opena, M, Subesinghe, S, Garrood, T, Menon, B, Ng, N, Douglas, K, Koutsianas, C, Cooles, F, Falahee, M, Echavez-Naguicnic, I, Bharadwaj, A, Villaruel, M, Pande, I, Collins, D, Pegler, S, Raizada, S, Siebert, S, Fragoulis, G, Guinto, J, Galloway, J, Rutherford, A, Barnes, T, Jeffrey, H, Patel, Y, Batley, M, O'Reilly, B, Venkatachalam, S, Sheeran, T, Gorman, C, Reynolds, P, Khan, A, Gullick, N, Banerjee, S, Mankia, K, Jordan, D, Rowlands, J, Starmans-Kool, M, Taylor, J, Nandi, P, Sahbudin, I, Maybury, M, Hider, S, Barcroft, A, Mcnally, J, Kitchen, J, Nisar, M & Quick, V 2024, 'Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial', The Lancet, vol. 403, pp. 838-849. https://doi.org/10.1016/s0140-6736(23)02649-1

TY - JOUR

T1 - Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial

AU - Cope, Andrew P

AU - Jasenecova, Marianna

AU - Vasconcelos, Joana C

AU - Filer, Andrew

AU - Raza, Karim

AU - Qureshi, Sumera

AU - D'Agostino, Maria Antonietta

AU - Mcinnes, Iain B

AU - Isaacs, John D

AU - Pratt, Arthur G

AU - Fisher, Benjamin A

AU - Buckley, Christopher D

AU - Emery, Paul

AU - Ho, Pauline

AU - Buch, Maya H

AU - Ciurtin, Coziana

AU - Van Schaardenburg, Dirkjan

AU - Huizinga, Thomas

AU - Toes, René

AU - Georgiou, Evangelos

AU - Kelly, Joanna

AU - Murphy, Caroline

AU - Prevost, A Toby

AU - Norton, Sam

AU - Lempp, Heidi

AU - Opena, Maria

AU - Subesinghe, Sujith

AU - Garrood, Toby

AU - Menon, Bina

AU - Ng, Nora

AU - Douglas, Karen

AU - Koutsianas, Christos

AU - Cooles, Faye

AU - Falahee, Marie

AU - Echavez-Naguicnic, Irene

AU - Bharadwaj, Anurag

AU - Villaruel, Michael

AU - Pande, Ira

AU - Collins, David

AU - Pegler, Suzannah

AU - Raizada, Sabrina

AU - Siebert, Stefan

AU - Fragoulis, George

AU - Guinto, Jesusa

AU - Galloway, James

AU - Rutherford, Andrew

AU - Barnes, Theresa

AU - Jeffrey, Helen

AU - Patel, Yusuf

AU - Batley, Michael

AU - O'Reilly, Brendan

AU - Venkatachalam, Srivinisan

AU - Sheeran, Thomas

AU - Gorman, Claire

AU - Reynolds, Piero

AU - Khan, Asad

AU - Gullick, Nicola

AU - Banerjee, Siwalik

AU - Mankia, Kulveer

AU - Jordan, Deepak

AU - Rowlands, Jane

AU - Starmans-Kool, Mirian

AU - Taylor, James

AU - Nandi, Pradip

AU - Sahbudin, Ilfita

AU - Maybury, Mark

AU - Hider, Samantha

AU - Barcroft, Ann

AU - Mcnally, Jeremy

AU - Kitchen, Jo

AU - Nisar, Muhammad

AU - Quick, Vanessa

PY - 2024

Y1 - 2024

KW - APIPPRA

KW - Abatacept

KW - phase 2b clinical trial

KW - rheumatoid arthritis

KW - APIPPRA

KW - Abatacept

KW - phase 2b clinical trial

KW - rheumatoid arthritis

UR - http://hdl.handle.net/10807/274463

U2 - 10.1016/s0140-6736(23)02649-1

DO - 10.1016/s0140-6736(23)02649-1

M3 - Article

SN - 0140-6736

VL - 403

SP - 838

EP - 849

JO - The Lancet

JF - The Lancet

ER -

Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial

Keywords

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