A) Successful MARS treatment in severe cholestatic patients with acute on chronic liver failure.

Rita Gaspari, Vittorio Mignani, Angelo Santoliquido, Giovanni Battista Gasbarrini, Antonio Gasbarrini, Cristiana Di Campli, Giovanna Stifano, Lorenzo Zileri Dal Verme, Rodolfo Proietti, Paolo Pola, Nicolo' Gentiloni Silveri

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Extracorporeal liver devices have gained great attention as a complementary approach to liver transplantation in patients with acute on chronic liver failure. Among others, Molecular Adsorbent Recycling System (MARS) is a hemodiafiltration against albumin able to remove low molecular weight toxins. We aimed to validate the use of MARS in patients presenting with acute on chronic liver failure with severe cholestasis. We enrolled 7 patients with acute on chronic liver failure, presenting with bilirubin >25 mg/dl and hepatorenal syndrome and/or hepatic encephalopathy grade >II. Liver biochemistry, coagulation, blood cell count, electrolytes, ammonia, lactate, blood urea nitrogen, creatinine, bile acids, Fischer ratio, and encephalopathy grade were assessed before and after each MARS treatment. MARS can represent a safe therapeutic choice to achieve a quick improvement of neurological status, a hemodynamic stability, and a better clinical outcome. In particular, our encouraging results suggest that also, patients with severe cholestasis may represent in the future a good indication for MARS treatment.
Original languageEnglish
Pages (from-to)565-569
Number of pages5
JournalArtificial Organs
Publication statusPublished - 2003

Keywords

  • MARS
  • cholestatic

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