A simulation environment for directional sensing as a phase separation process

Antonio De Candia; Andrea Gamba; Fausto Cavalli; Antonio Coniglio; Stefano Di Talia; Federico Bussolino; Guido Serini

doi:10.1126/stke.3782007pl1

A simulation environment for directional sensing as a phase separation process

Antonio De Candia
, Andrea Gamba
, Fausto Cavalli
, Antonio Coniglio
, Stefano Di Talia
, Federico Bussolino
, Guido Serini

Università Cattolica del Sacro Cuore

University of Naples Federico II

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.

Original language	English
Pages (from-to)	N/A-N/A
Journal	SCIENCE'S STKE: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT
Volume	2007
DOIs	https://doi.org/10.1126/stke.3782007pl1
Publication status	Published - 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cell Membrane
Chemotactic Factors
Chemotaxis
Computer Simulation
Computer Systems
Cytosol
Data Display
Eukaryotic Cells
Membrane Lipids
Membrane Proteins
Microcomputers
Models, Biological
Osmolar Concentration
Phosphatidylinositols
Software
Stochastic Processes

Access to Document

10.1126/stke.3782007pl1

Cite this

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title = "A simulation environment for directional sensing as a phase separation process",

abstract = "The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.",

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author = "\{De Candia\}, Antonio and Andrea Gamba and Fausto Cavalli and Antonio Coniglio and \{Di Talia\}, Stefano and Federico Bussolino and Guido Serini",

year = "2007",

doi = "10.1126/stke.3782007pl1",

language = "English",

volume = "2007",

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T1 - A simulation environment for directional sensing as a phase separation process

AU - De Candia, Antonio

AU - Gamba, Andrea

AU - Cavalli, Fausto

AU - Coniglio, Antonio

AU - Di Talia, Stefano

AU - Bussolino, Federico

AU - Serini, Guido

PY - 2007

Y1 - 2007

N2 - The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.

AB - The ability of eukaryotic cells to navigate along spatial gradients of extracellular guidance cues is crucial for embryonic development, tissue regeneration, and cancer progression. One proposed model for chemotaxis is a phosphoinositide-based phase separation process, which takes place at the plasma membrane upon chemoattractant stimulation and triggers directional motility of eukaryotic cells. Here, we make available virtual-cell software that allows the execution and spatiotemporal analysis of in silico chemotaxis experiments, in which the user can control physical and chemical parameters as well as the number and position of chemoattractant sources.

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KW - Chemotactic Factors

KW - Chemotaxis

KW - Computer Simulation

KW - Computer Systems

KW - Cytosol

KW - Data Display

KW - Eukaryotic Cells

KW - Membrane Lipids

KW - Membrane Proteins

KW - Microcomputers

KW - Models, Biological

KW - Osmolar Concentration

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KW - Stochastic Processes

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KW - Chemotactic Factors

KW - Chemotaxis

KW - Computer Simulation

KW - Computer Systems

KW - Cytosol

KW - Data Display

KW - Eukaryotic Cells

KW - Membrane Lipids

KW - Membrane Proteins

KW - Microcomputers

KW - Models, Biological

KW - Osmolar Concentration

KW - Phosphatidylinositols

KW - Software

KW - Stochastic Processes

UR - http://hdl.handle.net/10807/85717

U2 - 10.1126/stke.3782007pl1

DO - 10.1126/stke.3782007pl1

M3 - Article

SN - 1525-8882

VL - 2007

SP - N/A-N/A

JO - SCIENCE'S STKE: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT

JF - SCIENCE'S STKE: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT

ER -

A simulation environment for directional sensing as a phase separation process

Abstract

UN SDGs

Keywords

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