A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism

Gabriella Cadoni, Stefania Boccia, Gaetano Paludetti, Gualtiero Ricciardi, Livia Petrelli, Paolo Di Giannantonio, Dario Arzani, Arianna Giorgio, Emma De Feo, Manlio Pandolfini, Paola Galli'

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43 Citations (Scopus)

Abstract

The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).
Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalActa Otorhinolaryngologica Italica
Volume32
Publication statusPublished - 2012

Keywords

  • genetic polymorphisms
  • genetic susceptibilty
  • head and neck cancer

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