A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

Patrizio Pasqualetti; Cristina Bonomini; Gloria Dal Forno; Luca Paulon; Elena Sinforiani; Camillo Marra; Orazio Zanetti; Paolo Maria Rossini

doi:10.1007/BF03325217

A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

Patrizio Pasqualetti
, Cristina Bonomini
, Gloria Dal Forno
, Luca Paulon
, Elena Sinforiani
, Camillo Marra
, Orazio Zanetti^*
, Paolo Maria Rossini

^*Corresponding author

IRCCS Centro San Giovanni di Dio Fatebenefratelli - Brescia
IRCCS San Raffaele Pisana - Roma
Medical College of Wisconsin
IRCCS Fondazione Istituto Neurologico Casimiro Mondino - Pavia
Universita Campus Bio-Medico di Roma

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.

Original language	English
Pages (from-to)	102-110
Number of pages	8
Journal	Aging Clinical and Experimental Research
Volume	21
Issue number	2
DOIs	https://doi.org/10.1007/BF03325217
Publication status	Published - 2009

All Science Journal Classification (ASJC) codes

Ageing
Geriatrics and Gerontology

Keywords

APOE e4
Alzheimer Disease

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10.1007/BF03325217

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title = "A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease",

abstract = "Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.",

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T1 - A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

AU - Pasqualetti, Patrizio

AU - Bonomini, Cristina

AU - Dal Forno, Gloria

AU - Paulon, Luca

AU - Sinforiani, Elena

AU - Marra, Camillo

AU - Zanetti, Orazio

AU - Rossini, Paolo Maria

PY - 2009

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N2 - Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.

AB - Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer's disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, glial and neuronal origin. In this trial, we evaluated whether the non-selective NSAID ibuprofen slows disease progression in patients with mild to moderate AD.

KW - APOE e4

KW - Alzheimer Disease

KW - APOE e4

KW - Alzheimer Disease

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A Randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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