A PALB2 germline mutation associated with hereditary breast cancer in Italy

Laura Papi, Anna Laura Putignano, Caterina Congregati, Irene Piaceri, Ines Zanna, Francesco Sera, Doralba Morrone, Maurizio Genuardi, Domenico Palli

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41 Citations (Scopus)

Abstract

Recently, it has been demonstrated that monoallelic PALB2 mutations predispose to familial breast cancer. We investigated the contribution of PALB2 mutations in a set of 132 Italian BRCA1/BRCA2-negative breast cancer families; one truncating PALB2 mutation, c.2257C>T, resulting in p.Arg753X, was identified in a woman and her daughter, with breast cancer diagnosed at 60 and 31 years old, respectively. This study supports the recent observation that PALB2 mutation are present, although infrequently, in familial BRCA1/BRCA2-negative breast cancer cases; moreover, it sustains latest evidences that some PALB2 mutations are associated with a substantially increased risk of breast cancer.
Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalFamilial Cancer
Volume9
DOIs
Publication statusPublished - 2010

Keywords

  • BRCA1/BRCA2
  • BRCA2
  • FAMILIES
  • FANCONI-ANEMIA
  • PREVALENCE
  • SUSCEPTIBILITY GENES
  • WOMEN

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