A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality

Matteo Bassetti, Elda Righi, Filippo Ansaldi, Maria Merelli, Claudio Scarparo, Massimo Antonelli, Jose Garnacho-Montero, Ana Diaz-Martin, Inmaculada Palacios-Garcia, Roberto Luzzati, Chiara Rosin, Leonel Lagunes, Jordi Rello, Benito Almirante, Pier Giorgio Scotton, Gianmaria Baldin, George Dimopoulos, Marcio Nucci, Patricia Munoz, Antonio VenaEmilio Bouza, Viviana De Egea, Arnaldo Lopes Colombo, Carlo Tascini, Francesco Menichetti, Enrico Tagliaferri, Pierluigi Brugnaro, Maurizio Sanguinetti, Alessio Mesini, Gabriele Sganga, Claudio Viscoli, Mario Tumbarello

Research output: Contribution to journalArticle

105 Citations (Scopus)


Purpose: Clinical data on patients with intra-abdominal candidiasis (IAC) is still scarce. Methods: We collected data from 13 hospitals in Italy, Spain, Brazil, and Greece over a 3-year period (2011–2013) including patients from ICU, medical, and surgical wards. Results: A total of 481 patients were included in the study. Of these, 27 % were hospitalized in ICU. Mean age was 63 years and 57 % of patients were male. IAC mainly consisted of secondary peritonitis (41 %) and abdominal abscesses (30 %); 68 (14 %) cases were also candidemic and 331 (69 %) had concomitant bacterial infections. The most commonly isolated Candida species were C. albicans (n = 308 isolates, 64 %) and C. glabrata (n = 76, 16 %). Antifungal treatment included echinocandins (64 %), azoles (32 %), and amphotericin B (4 %). Septic shock was documented in 40.5 % of patients. Overall 30-day hospital mortality was 27 % with 38.9 % mortality in ICU. Multivariate logistic regression showed that age (OR 1.05, 95 % CI 1.03–1.07, P\0.001), increments in 1-point APACHE II scores (OR 1.05, 95 % CI 1.01–1.08, P = 0.028), secondary peritonitis (OR 1.72, 95 % CI 1.02–2.89, P = 0.019), septic shock (OR 3.29, 95 % CI 1.88–5.86, P\0.001), and absence of adequate abdominal source control (OR 3.35, 95 % CI 2.01–5.63, P\0.001) were associated with mortality. In patients with septic shock, absence of source control correlated with mortality rates above 60 % irrespective of administration of an adequate antifungal therapy. Conclusions: Low percentages of concomitant candidemia and high mortality rates are documented in IAC. In patients presenting with septic shock, source control is fundamental
Original languageEnglish
Pages (from-to)1601-1610
Number of pages10
JournalIntensive Care Medicine
Publication statusPublished - 2015


  • abdominal candidiasis
  • candida


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