A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions

R. John Wallace; Goor Sasson; Philip C. Garnsworthy; Ilma Tapio; Emma Gregson; Paolo Bani; Pekka Huhtanen; Ali R. Bayat; Francesco Strozzi; Filippo Biscarini; Timothy J. Snelling; Neil Saunders; Sarah L. Potterton; James Craigon; Andrea Minuti; Erminio Trevisi; Maria Luisa Callegari; Fiorenzo Piccioli Cappelli; Edward H. Cabezas-Garcia; Johanna Vilkki; Cesar Pinares-Patino; Kateřina O. Fliegerová; Jakub Mrázek; Hana Sechovcová; Jan Kopečný; Aurélie Bonin; Frédéric Boyer; Pierre Taberlet; Fotini Kokou; Eran Halperin; John L. Williams; Kevin J. Shingfield; Itzhak Mizrahi

doi:10.1126/sciadv.aav8391

A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions

R. John Wallace, Goor Sasson, Philip C. Garnsworthy, Ilma Tapio, Emma Gregson, Paolo Bani, Pekka Huhtanen, Ali R. Bayat, Francesco Strozzi, Filippo Biscarini, Timothy J. Snelling, Neil Saunders, Sarah L. Potterton, James Craigon, Andrea Minuti, Erminio Trevisi, Maria Luisa Callegari, Fiorenzo Piccioli Cappelli, Edward H. Cabezas-Garcia, Johanna VilkkiCesar Pinares-Patino, Kateřina O. Fliegerová, Jakub Mrázek, Hana Sechovcová, Jan Kopečný, Aurélie Bonin, Frédéric Boyer, Pierre Taberlet, Fotini Kokou, Eran Halperin, John L. Williams, Kevin J. Shingfield, Itzhak Mizrahi

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Abstract

A 1000-cow study across four European countries was undertaken to understand to what extent ruminant microbiomes can be controlled by the host animal and to identify characteristics of the host rumen microbiome axis that determine productivity and methane emissions. A core rumen microbiome, phylogenetically linked and with a preserved hierarchical structure, was identified. A 39-member subset of the core formed hubs in co-occurrence networks linking microbiome structure to host genetics and phenotype (methane emissions, rumen and blood metabolites, and milk production efficiency). These phenotypes can be predicted from the core microbiome using machine learning algorithms. The heritable core microbes, therefore, present primary targets for rumen manipulation toward sustainable and environmentally friendly agriculture.

Original language	English
Pages (from-to)	eaav8391-N/A
Journal	Science advances
Volume	5
DOIs	https://doi.org/10.1126/sciadv.aav8391
Publication status	Published - 2019

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inglese

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John Wallace, R., Sasson, G., Garnsworthy, P. C., Tapio, I., Gregson, E., Bani, P., Huhtanen, P., Bayat, A. R., Strozzi, F., Biscarini, F., Snelling, T. J., Saunders, N., Potterton, S. L., Craigon, J., Minuti, A., Trevisi, E., Callegari, M. L., Piccioli Cappelli, F., Cabezas-Garcia, E. H., ... Mizrahi, I. (2019). A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions. Science advances, 5, eaav8391-N/A. https://doi.org/10.1126/sciadv.aav8391

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title = "A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions",

abstract = "A 1000-cow study across four European countries was undertaken to understand to what extent ruminant microbiomes can be controlled by the host animal and to identify characteristics of the host rumen microbiome axis that determine productivity and methane emissions. A core rumen microbiome, phylogenetically linked and with a preserved hierarchical structure, was identified. A 39-member subset of the core formed hubs in co-occurrence networks linking microbiome structure to host genetics and phenotype (methane emissions, rumen and blood metabolites, and milk production efficiency). These phenotypes can be predicted from the core microbiome using machine learning algorithms. The heritable core microbes, therefore, present primary targets for rumen manipulation toward sustainable and environmentally friendly agriculture.",

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author = "{John Wallace}, R. and Goor Sasson and Garnsworthy, {Philip C.} and Ilma Tapio and Emma Gregson and Paolo Bani and Pekka Huhtanen and Bayat, {Ali R.} and Francesco Strozzi and Filippo Biscarini and Snelling, {Timothy J.} and Neil Saunders and Potterton, {Sarah L.} and James Craigon and Andrea Minuti and Erminio Trevisi and Callegari, {Maria Luisa} and {Piccioli Cappelli}, Fiorenzo and Cabezas-Garcia, {Edward H.} and Johanna Vilkki and Cesar Pinares-Patino and Fliegerov{\'a}, {Kate{\v r}ina O.} and Jakub Mr{\'a}zek and Hana Sechovcov{\'a} and Jan Kope{\v c}n{\'y} and Aur{\'e}lie Bonin and Fr{\'e}d{\'e}ric Boyer and Pierre Taberlet and Fotini Kokou and Eran Halperin and Williams, {John L.} and Shingfield, {Kevin J.} and Itzhak Mizrahi",

year = "2019",

doi = "10.1126/sciadv.aav8391",

language = "English",

volume = "5",

pages = "eaav8391--N/A",

journal = "Science advances",

issn = "2375-2548",

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John Wallace, R, Sasson, G, Garnsworthy, PC, Tapio, I, Gregson, E, Bani, P, Huhtanen, P, Bayat, AR, Strozzi, F, Biscarini, F, Snelling, TJ, Saunders, N, Potterton, SL, Craigon, J, Minuti, A , Trevisi, E , Callegari, ML , Piccioli Cappelli, F, Cabezas-Garcia, EH, Vilkki, J, Pinares-Patino, C, Fliegerová, KO, Mrázek, J, Sechovcová, H, Kopečný, J, Bonin, A, Boyer, F, Taberlet, P, Kokou, F, Halperin, E, Williams, JL, Shingfield, KJ & Mizrahi, I 2019, 'A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions', Science advances, vol. 5, pp. eaav8391-N/A. https://doi.org/10.1126/sciadv.aav8391

TY - JOUR

T1 - A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions

AU - John Wallace, R.

AU - Sasson, Goor

AU - Garnsworthy, Philip C.

AU - Tapio, Ilma

AU - Gregson, Emma

AU - Bani, Paolo

AU - Huhtanen, Pekka

AU - Bayat, Ali R.

AU - Strozzi, Francesco

AU - Biscarini, Filippo

AU - Snelling, Timothy J.

AU - Saunders, Neil

AU - Potterton, Sarah L.

AU - Craigon, James

AU - Minuti, Andrea

AU - Trevisi, Erminio

AU - Callegari, Maria Luisa

AU - Piccioli Cappelli, Fiorenzo

AU - Cabezas-Garcia, Edward H.

AU - Vilkki, Johanna

AU - Pinares-Patino, Cesar

AU - Fliegerová, Kateřina O.

AU - Mrázek, Jakub

AU - Sechovcová, Hana

AU - Kopečný, Jan

AU - Bonin, Aurélie

AU - Boyer, Frédéric

AU - Taberlet, Pierre

AU - Kokou, Fotini

AU - Halperin, Eran

AU - Williams, John L.

AU - Shingfield, Kevin J.

AU - Mizrahi, Itzhak

PY - 2019

Y1 - 2019

N2 - A 1000-cow study across four European countries was undertaken to understand to what extent ruminant microbiomes can be controlled by the host animal and to identify characteristics of the host rumen microbiome axis that determine productivity and methane emissions. A core rumen microbiome, phylogenetically linked and with a preserved hierarchical structure, was identified. A 39-member subset of the core formed hubs in co-occurrence networks linking microbiome structure to host genetics and phenotype (methane emissions, rumen and blood metabolites, and milk production efficiency). These phenotypes can be predicted from the core microbiome using machine learning algorithms. The heritable core microbes, therefore, present primary targets for rumen manipulation toward sustainable and environmentally friendly agriculture.

AB - A 1000-cow study across four European countries was undertaken to understand to what extent ruminant microbiomes can be controlled by the host animal and to identify characteristics of the host rumen microbiome axis that determine productivity and methane emissions. A core rumen microbiome, phylogenetically linked and with a preserved hierarchical structure, was identified. A 39-member subset of the core formed hubs in co-occurrence networks linking microbiome structure to host genetics and phenotype (methane emissions, rumen and blood metabolites, and milk production efficiency). These phenotypes can be predicted from the core microbiome using machine learning algorithms. The heritable core microbes, therefore, present primary targets for rumen manipulation toward sustainable and environmentally friendly agriculture.

KW - inglese

UR - http://hdl.handle.net/10807/146908

UR - https://advances.sciencemag.org/content/5/7/eaav8391/tab-pdf

U2 - 10.1126/sciadv.aav8391

DO - 10.1126/sciadv.aav8391

M3 - Article

SN - 2375-2548

VL - 5

SP - eaav8391-N/A

JO - Science advances

JF - Science advances

ER -

A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions

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Keywords

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