A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study

Daniel Munblit; Timothy Nicholson; Athena Akrami; Christian Apfelbacher; Jessica Chen; Wouter De Groote; Janet V Diaz; Sarah L Gorst; Nicola Harman; Alisa Kokorina; Piero Olliaro; Callum Parr; Jacobus Preller; Nicoline Schiess; Jochen Schmitt; Nina Seylanova; Frances Simpson; Allison Tong; Dale M Needham; Paula R Williamson; Alla Guekht; Malcolm “Calum” G. Semple; John O. Warner; Louise Sigfrid; Janet T. Scott; Audrey Dunngalvin; Jon Genuneit; Danilo Buonsenso; Manoj Sivan; Bob Siegerink; Frederikus A. Klok; Sergey Avdeev; Charitini Stavropoulou; Melina Michelen; Olalekan Lee Aiyegbusi; Melanie Calvert; Sarah E. Hughes; Shamil Haroon; Laura Fregonese; Gail Carson; Samuel Knauss; Margaret O'Hara; John Marshall; Margaret Herridge; Srinivas Murthy; Theo Vos; Sarah Wulf Hanson; Ann Parker; Kelly K. O'Brien; Andrea Lerner; Jennifer R. Chevinsky; Elizabeth R. Unger; Robert W. Eisinger; Catherine L. Hough; Sharon Saydah; Jennifer A. Frontera; Regis Goulart Rosa; Bin Cao; Shinjini Bhatnagar; Ramachandran Thiruvengadam; Archana Seahwag; Anouar Bouraoui; Maria Van Kerkhove; Tarun Dua; Pryanka Relan; Juan Soriano Ortiz

doi:10.1016/S2213-2600(22)00169-2

A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study

Daniel Munblit, Timothy Nicholson, Athena Akrami, Christian Apfelbacher, Jessica Chen, Wouter De Groote, Janet V Diaz, Sarah L Gorst, Nicola Harman, Alisa Kokorina, Piero Olliaro, Callum Parr, Jacobus Preller, Nicoline Schiess, Jochen Schmitt, Nina Seylanova, Frances Simpson, Allison Tong, Dale M Needham, Paula R WilliamsonAlla Guekht, Malcolm “Calum” G. Semple, John O. Warner, Louise Sigfrid, Janet T. Scott, Audrey Dunngalvin, Jon Genuneit, Danilo Buonsenso, Manoj Sivan, Bob Siegerink, Frederikus A. Klok, Sergey Avdeev, Charitini Stavropoulou, Melina Michelen, Olalekan Lee Aiyegbusi, Melanie Calvert, Sarah E. Hughes, Shamil Haroon, Laura Fregonese, Gail Carson, Samuel Knauss, Margaret O'Hara, John Marshall, Margaret Herridge, Srinivas Murthy, Theo Vos, Sarah Wulf Hanson, Ann Parker, Kelly K. O'Brien, Andrea Lerner, Jennifer R. Chevinsky, Elizabeth R. Unger, Robert W. Eisinger, Catherine L. Hough, Sharon Saydah, Jennifer A. Frontera, Regis Goulart Rosa, Bin Cao, Shinjini Bhatnagar, Ramachandran Thiruvengadam, Archana Seahwag, Anouar Bouraoui, Maria Van Kerkhove, Tarun Dua, Pryanka Relan, Juan Soriano Ortiz

Research output: Contribution to journal › Article

Abstract

Health consequences that persist beyond the acute infection phase of COVID-19, termed post-COVID-19 condition (also commonly known as long COVID), vary widely and represent a growing global health challenge. Research on post-COVID-19 condition is expanding but, at present, no agreement exists on the health outcomes that should be measured in people living with the condition. To address this gap, we conducted an international consensus study, which included a comprehensive literature review and classification of outcomes for post-COVID-19 condition that informed a two-round online modified Delphi process followed by an online consensus meeting to finalise the core outcome set (COS). 1535 participants from 71 countries were involved, with 1148 individuals participating in both Delphi rounds. Eleven outcomes achieved consensus for inclusion in the final COS: fatigue; pain; post-exertion symptoms; work or occupational and study changes; survival; and functioning, symptoms, and conditions for each of cardiovascular, respiratory, nervous system, cognitive, mental health, and physical outcomes. Recovery was included a priori because it was a relevant outcome that was part of a previously published COS on COVID-19. The next step in this COS development exercise will be to establish the instruments that are most appropriate to measure these core outcomes. This international consensus-based COS should provide a framework for standardised assessment of adults with post-COVID-19 condition, aimed at facilitating clinical care and research worldwide.

Original language	English
Pages (from-to)	715-724
Number of pages	10
Journal	The Lancet Respiratory Medicine
Volume	10
DOIs	https://doi.org/10.1016/S2213-2600(22)00169-2
Publication status	Published - 2022

Keywords

N/A

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S2213-2600(22)00169-2

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Munblit, D., Nicholson, T., Akrami, A., Apfelbacher, C., Chen, J., De Groote, W., Diaz, J. V., Gorst, S. L., Harman, N., Kokorina, A., Olliaro, P., Parr, C., Preller, J., Schiess, N., Schmitt, J., Seylanova, N., Simpson, F., Tong, A., Needham, D. M., ... Soriano Ortiz, J. (2022). A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study. The Lancet Respiratory Medicine, 10, 715-724. https://doi.org/10.1016/S2213-2600(22)00169-2

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title = "A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study",

abstract = "Health consequences that persist beyond the acute infection phase of COVID-19, termed post-COVID-19 condition (also commonly known as long COVID), vary widely and represent a growing global health challenge. Research on post-COVID-19 condition is expanding but, at present, no agreement exists on the health outcomes that should be measured in people living with the condition. To address this gap, we conducted an international consensus study, which included a comprehensive literature review and classification of outcomes for post-COVID-19 condition that informed a two-round online modified Delphi process followed by an online consensus meeting to finalise the core outcome set (COS). 1535 participants from 71 countries were involved, with 1148 individuals participating in both Delphi rounds. Eleven outcomes achieved consensus for inclusion in the final COS: fatigue; pain; post-exertion symptoms; work or occupational and study changes; survival; and functioning, symptoms, and conditions for each of cardiovascular, respiratory, nervous system, cognitive, mental health, and physical outcomes. Recovery was included a priori because it was a relevant outcome that was part of a previously published COS on COVID-19. The next step in this COS development exercise will be to establish the instruments that are most appropriate to measure these core outcomes. This international consensus-based COS should provide a framework for standardised assessment of adults with post-COVID-19 condition, aimed at facilitating clinical care and research worldwide.",

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author = "Daniel Munblit and Timothy Nicholson and Athena Akrami and Christian Apfelbacher and Jessica Chen and {De Groote}, Wouter and Diaz, {Janet V} and Gorst, {Sarah L} and Nicola Harman and Alisa Kokorina and Piero Olliaro and Callum Parr and Jacobus Preller and Nicoline Schiess and Jochen Schmitt and Nina Seylanova and Frances Simpson and Allison Tong and Needham, {Dale M} and Williamson, {Paula R} and Alla Guekht and Semple, {Malcolm “Calum” G.} and Warner, {John O.} and Louise Sigfrid and Scott, {Janet T.} and Audrey Dunngalvin and Jon Genuneit and Danilo Buonsenso and Manoj Sivan and Bob Siegerink and Klok, {Frederikus A.} and Sergey Avdeev and Charitini Stavropoulou and Melina Michelen and Aiyegbusi, {Olalekan Lee} and Melanie Calvert and Hughes, {Sarah E.} and Shamil Haroon and Laura Fregonese and Gail Carson and Samuel Knauss and Margaret O'Hara and John Marshall and Margaret Herridge and Srinivas Murthy and Theo Vos and {Wulf Hanson}, Sarah and Ann Parker and O'Brien, {Kelly K.} and Andrea Lerner and Chevinsky, {Jennifer R.} and Unger, {Elizabeth R.} and Eisinger, {Robert W.} and Hough, {Catherine L.} and Sharon Saydah and Frontera, {Jennifer A.} and Rosa, {Regis Goulart} and Bin Cao and Shinjini Bhatnagar and Ramachandran Thiruvengadam and Archana Seahwag and Anouar Bouraoui and {Van Kerkhove}, Maria and Tarun Dua and Pryanka Relan and {Soriano Ortiz}, Juan",

year = "2022",

doi = "10.1016/S2213-2600(22)00169-2",

language = "English",

volume = "10",

pages = "715--724",

journal = "The Lancet Respiratory Medicine",

issn = "2213-2600",

publisher = "Elsevier Ltd",

}

Munblit, D, Nicholson, T, Akrami, A, Apfelbacher, C, Chen, J, De Groote, W, Diaz, JV, Gorst, SL, Harman, N, Kokorina, A, Olliaro, P, Parr, C, Preller, J, Schiess, N, Schmitt, J, Seylanova, N, Simpson, F, Tong, A, Needham, DM, Williamson, PR, Guekht, A, Semple, MCG, Warner, JO, Sigfrid, L, Scott, JT, Dunngalvin, A, Genuneit, J, Buonsenso, D, Sivan, M, Siegerink, B, Klok, FA, Avdeev, S, Stavropoulou, C, Michelen, M, Aiyegbusi, OL, Calvert, M, Hughes, SE, Haroon, S, Fregonese, L, Carson, G, Knauss, S, O'Hara, M, Marshall, J, Herridge, M, Murthy, S, Vos, T, Wulf Hanson, S, Parker, A, O'Brien, KK, Lerner, A, Chevinsky, JR, Unger, ER, Eisinger, RW, Hough, CL, Saydah, S, Frontera, JA, Rosa, RG, Cao, B, Bhatnagar, S, Thiruvengadam, R, Seahwag, A, Bouraoui, A, Van Kerkhove, M, Dua, T, Relan, P & Soriano Ortiz, J 2022, 'A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study', The Lancet Respiratory Medicine, vol. 10, pp. 715-724. https://doi.org/10.1016/S2213-2600(22)00169-2

TY - JOUR

T1 - A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study

AU - Munblit, Daniel

AU - Nicholson, Timothy

AU - Akrami, Athena

AU - Apfelbacher, Christian

AU - Chen, Jessica

AU - De Groote, Wouter

AU - Diaz, Janet V

AU - Gorst, Sarah L

AU - Harman, Nicola

AU - Kokorina, Alisa

AU - Olliaro, Piero

AU - Parr, Callum

AU - Preller, Jacobus

AU - Schiess, Nicoline

AU - Schmitt, Jochen

AU - Seylanova, Nina

AU - Simpson, Frances

AU - Tong, Allison

AU - Needham, Dale M

AU - Williamson, Paula R

AU - Guekht, Alla

AU - Semple, Malcolm “Calum” G.

AU - Warner, John O.

AU - Sigfrid, Louise

AU - Scott, Janet T.

AU - Dunngalvin, Audrey

AU - Genuneit, Jon

AU - Buonsenso, Danilo

AU - Sivan, Manoj

AU - Siegerink, Bob

AU - Klok, Frederikus A.

AU - Avdeev, Sergey

AU - Stavropoulou, Charitini

AU - Michelen, Melina

AU - Aiyegbusi, Olalekan Lee

AU - Calvert, Melanie

AU - Hughes, Sarah E.

AU - Haroon, Shamil

AU - Fregonese, Laura

AU - Carson, Gail

AU - Knauss, Samuel

AU - O'Hara, Margaret

AU - Marshall, John

AU - Herridge, Margaret

AU - Murthy, Srinivas

AU - Vos, Theo

AU - Wulf Hanson, Sarah

AU - Parker, Ann

AU - O'Brien, Kelly K.

AU - Lerner, Andrea

AU - Chevinsky, Jennifer R.

AU - Unger, Elizabeth R.

AU - Eisinger, Robert W.

AU - Hough, Catherine L.

AU - Saydah, Sharon

AU - Frontera, Jennifer A.

AU - Rosa, Regis Goulart

AU - Cao, Bin

AU - Bhatnagar, Shinjini

AU - Thiruvengadam, Ramachandran

AU - Seahwag, Archana

AU - Bouraoui, Anouar

AU - Van Kerkhove, Maria

AU - Dua, Tarun

AU - Relan, Pryanka

AU - Soriano Ortiz, Juan

PY - 2022

Y1 - 2022

N2 - Health consequences that persist beyond the acute infection phase of COVID-19, termed post-COVID-19 condition (also commonly known as long COVID), vary widely and represent a growing global health challenge. Research on post-COVID-19 condition is expanding but, at present, no agreement exists on the health outcomes that should be measured in people living with the condition. To address this gap, we conducted an international consensus study, which included a comprehensive literature review and classification of outcomes for post-COVID-19 condition that informed a two-round online modified Delphi process followed by an online consensus meeting to finalise the core outcome set (COS). 1535 participants from 71 countries were involved, with 1148 individuals participating in both Delphi rounds. Eleven outcomes achieved consensus for inclusion in the final COS: fatigue; pain; post-exertion symptoms; work or occupational and study changes; survival; and functioning, symptoms, and conditions for each of cardiovascular, respiratory, nervous system, cognitive, mental health, and physical outcomes. Recovery was included a priori because it was a relevant outcome that was part of a previously published COS on COVID-19. The next step in this COS development exercise will be to establish the instruments that are most appropriate to measure these core outcomes. This international consensus-based COS should provide a framework for standardised assessment of adults with post-COVID-19 condition, aimed at facilitating clinical care and research worldwide.

AB - Health consequences that persist beyond the acute infection phase of COVID-19, termed post-COVID-19 condition (also commonly known as long COVID), vary widely and represent a growing global health challenge. Research on post-COVID-19 condition is expanding but, at present, no agreement exists on the health outcomes that should be measured in people living with the condition. To address this gap, we conducted an international consensus study, which included a comprehensive literature review and classification of outcomes for post-COVID-19 condition that informed a two-round online modified Delphi process followed by an online consensus meeting to finalise the core outcome set (COS). 1535 participants from 71 countries were involved, with 1148 individuals participating in both Delphi rounds. Eleven outcomes achieved consensus for inclusion in the final COS: fatigue; pain; post-exertion symptoms; work or occupational and study changes; survival; and functioning, symptoms, and conditions for each of cardiovascular, respiratory, nervous system, cognitive, mental health, and physical outcomes. Recovery was included a priori because it was a relevant outcome that was part of a previously published COS on COVID-19. The next step in this COS development exercise will be to establish the instruments that are most appropriate to measure these core outcomes. This international consensus-based COS should provide a framework for standardised assessment of adults with post-COVID-19 condition, aimed at facilitating clinical care and research worldwide.

KW - N/A

UR - http://hdl.handle.net/10807/303805

U2 - 10.1016/S2213-2600(22)00169-2

DO - 10.1016/S2213-2600(22)00169-2

M3 - Article

SN - 2213-2600

VL - 10

SP - 715

EP - 724

JO - The Lancet Respiratory Medicine

JF - The Lancet Respiratory Medicine

ER -

A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study

Abstract

Keywords

UN SDGs

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