68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

Filippo Lococo; Vittoria Rufini; Angelina Filice; Massimiliano Paci; Guido Rindi

doi:10.1097/RLU.0000000000003570

68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

Filippo Lococo, Vittoria Rufini, Angelina Filice, Massimiliano Paci, Guido Rindi

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Abstract

ABSTRACT: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Clinical Nuclear Medicine
Volume	Publish Ahead of Print
DOIs	https://doi.org/10.1097/RLU.0000000000003570
Publication status	Published - 2021

Keywords

68Ga-DOTATOC PET/CT

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10.1097/RLU.0000000000003570

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title = "68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors",

abstract = "ABSTRACT: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.",

keywords = "68Ga-DOTATOC PET/CT, 68Ga-DOTATOC PET/CT",

author = "Filippo Lococo and Vittoria Rufini and Angelina Filice and Massimiliano Paci and Guido Rindi",

year = "2021",

doi = "10.1097/RLU.0000000000003570",

language = "English",

volume = "Publish Ahead of Print",

pages = "N/A--N/A",

journal = "Clinical Nuclear Medicine",

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publisher = "Lippincott Williams and Wilkins Ltd.",

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TY - JOUR

T1 - 68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

AU - Lococo, Filippo

AU - Rufini, Vittoria

AU - Filice, Angelina

AU - Paci, Massimiliano

AU - Rindi, Guido

PY - 2021

Y1 - 2021

N2 - ABSTRACT: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

AB - ABSTRACT: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

KW - 68Ga-DOTATOC PET/CT

UR - http://hdl.handle.net/10807/178546

U2 - 10.1097/RLU.0000000000003570

DO - 10.1097/RLU.0000000000003570

M3 - Article

SN - 0363-9762

VL - Publish Ahead of Print

SP - N/A-N/A

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

ER -

68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

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