2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

L. Gaetani; L. Prosperini; A. Mancini; P. Eusebi; M. C. Cerri; C. Pozzilli; Paolo Calabresi; P. Sarchielli; Filippo M. Di

doi:10.1007/s00415-018-9048-8

2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

L. Gaetani
, L. Prosperini
, A. Mancini
, P. Eusebi
, M. C. Cerri
, C. Pozzilli
, Paolo Calabresi
, P. Sarchielli
, Filippo M. Di^*

^*Corresponding author

University of Perugia
San Camillo Hospital
Sapienza University of Rome

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

Objectives: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. Methods: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Results: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. Conclusions: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.

Original language	English
Pages (from-to)	2684-2687
Number of pages	4
Journal	Journal of Neurology
Volume	265
Issue number	11
DOIs	https://doi.org/10.1007/s00415-018-9048-8
Publication status	Published - 2018

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

Keywords

Adult
Biomarkers
Clinically isolated syndrome
Conversion
Demyelinating Diseases
Diagnostic criteria
Dissemination in space
Dissemination in time
Female
Follow-Up Studies
Humans
Immunologic Factors
Magnetic Resonance Imaging
Male
Multiple sclerosis
Oligoclonal bands
Retrospective Studies
Symptomatic gadolinium enhancing lesion
Time Factors

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10.1007/s00415-018-9048-8

Cite this

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title = "2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes",

abstract = "Objectives: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. Methods: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Results: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5\% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8\% of these patients eventually satisfied also the previous (2010) criteria. Conclusions: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.",

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author = "L. Gaetani and L. Prosperini and A. Mancini and P. Eusebi and Cerri, \{M. C.\} and C. Pozzilli and Paolo Calabresi and P. Sarchielli and Di, \{Filippo M.\}",

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doi = "10.1007/s00415-018-9048-8",

language = "English",

volume = "265",

pages = "2684--2687",

journal = "Journal of Neurology",

issn = "0340-5354",

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TY - JOUR

T1 - 2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

AU - Gaetani, L.

AU - Prosperini, L.

AU - Mancini, A.

AU - Eusebi, P.

AU - Cerri, M. C.

AU - Pozzilli, C.

AU - Calabresi, Paolo

AU - Sarchielli, P.

AU - Di, Filippo M.

PY - 2018

Y1 - 2018

N2 - Objectives: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. Methods: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Results: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. Conclusions: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.

AB - Objectives: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. Methods: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Results: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. Conclusions: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.

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KW - Conversion

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KW - Diagnostic criteria

KW - Dissemination in space

KW - Dissemination in time

KW - Female

KW - Follow-Up Studies

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KW - Dissemination in time

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KW - Follow-Up Studies

KW - Humans

KW - Immunologic Factors

KW - Magnetic Resonance Imaging

KW - Male

KW - Multiple sclerosis

KW - Oligoclonal bands

KW - Retrospective Studies

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KW - Time Factors

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JO - Journal of Neurology

JF - Journal of Neurology

IS - 11

ER -

2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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