2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

Paolo Calabresi, Lorenzo Gaetani, Luca Prosperini, Andrea Mancini, Paolo Eusebi, Maria Chiara Cerri, Carlo Pozzilli, Paola Sarchielli, Massimiliano Di Filippo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objectives: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. Methods: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Results: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. Conclusions: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.
Original languageEnglish
Pages (from-to)2684-2687
Number of pages4
JournalJournal of Neurology
Volume265
DOIs
Publication statusPublished - 2018

Keywords

  • Adult
  • Biomarkers
  • Clinically isolated syndrome
  • Conversion
  • Demyelinating Diseases
  • Diagnostic criteria
  • Dissemination in space
  • Dissemination in time
  • Female
  • Follow-Up Studies
  • Humans
  • Immunologic Factors
  • Magnetic Resonance Imaging
  • Male
  • Multiple sclerosis
  • Oligoclonal bands
  • Retrospective Studies
  • Symptomatic gadolinium enhancing lesion
  • Time Factors

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