2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

Lorenzo Gaetani; Luca Prosperini; Andrea Mancini; Paolo Eusebi; Maria Chiara Cerri; Carlo Pozzilli; Paolo Calabresi; Paola Sarchielli; Massimiliano Di Filippo

doi:10.1007/s00415-018-9048-8

2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

Lorenzo Gaetani, Luca Prosperini, Andrea Mancini, Paolo Eusebi, Maria Chiara Cerri, Carlo Pozzilli, Paolo Calabresi, Paola Sarchielli, Massimiliano Di Filippo

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Abstract

Objectives: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. Methods: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Results: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. Conclusions: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.

Original language	English
Pages (from-to)	2684-2687
Number of pages	4
Journal	Journal of Neurology
Volume	265
DOIs	https://doi.org/10.1007/s00415-018-9048-8
Publication status	Published - 2018

Keywords

Adult
Biomarkers
Clinically isolated syndrome
Conversion
Demyelinating Diseases
Diagnostic criteria
Dissemination in space
Dissemination in time
Female
Follow-Up Studies
Humans
Immunologic Factors
Magnetic Resonance Imaging
Male
Multiple sclerosis
Oligoclonal bands
Retrospective Studies
Symptomatic gadolinium enhancing lesion
Time Factors

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10.1007/s00415-018-9048-8

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title = "2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes",

abstract = "Objectives: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. Methods: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Results: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. Conclusions: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.",

keywords = "Adult, Biomarkers, Clinically isolated syndrome, Conversion, Demyelinating Diseases, Diagnostic criteria, Dissemination in space, Dissemination in time, Female, Follow-Up Studies, Humans, Immunologic Factors, Magnetic Resonance Imaging, Male, Multiple sclerosis, Oligoclonal bands, Retrospective Studies, Symptomatic gadolinium enhancing lesion, Time Factors, Adult, Biomarkers, Clinically isolated syndrome, Conversion, Demyelinating Diseases, Diagnostic criteria, Dissemination in space, Dissemination in time, Female, Follow-Up Studies, Humans, Immunologic Factors, Magnetic Resonance Imaging, Male, Multiple sclerosis, Oligoclonal bands, Retrospective Studies, Symptomatic gadolinium enhancing lesion, Time Factors",

author = "Lorenzo Gaetani and Luca Prosperini and Andrea Mancini and Paolo Eusebi and Cerri, {Maria Chiara} and Carlo Pozzilli and Paolo Calabresi and Paola Sarchielli and {Di Filippo}, Massimiliano",

year = "2018",

doi = "10.1007/s00415-018-9048-8",

language = "English",

volume = "265",

pages = "2684--2687",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: [email protected], INTERNET: http://www.springer.de, Fax: 011 49 6221 345229",

}

TY - JOUR

T1 - 2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

AU - Gaetani, Lorenzo

AU - Prosperini, Luca

AU - Mancini, Andrea

AU - Eusebi, Paolo

AU - Cerri, Maria Chiara

AU - Pozzilli, Carlo

AU - Calabresi, Paolo

AU - Sarchielli, Paola

AU - Di Filippo, Massimiliano

PY - 2018

Y1 - 2018

N2 - Objectives: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. Methods: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Results: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. Conclusions: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.

AB - Objectives: To investigate the impact of the 2017 revisions of McDonald criteria on the diagnosis of multiple sclerosis (MS) in a cohort of patients with clinically isolated syndrome (CIS) and dissemination in space (DIS) of demyelinating lesions. Methods: We retrospectively analyzed 137 patients with CIS + DIS from two Italian MS centers. Results: Application of the 2017 revisions of McDonald criteria in our cohort led to a diagnosis of MS in 82.5% of the patients who could have not been diagnosed with MS according to the previous criteria at the time of the first demyelinating event. After a follow-up of 3.8 ± 2.9 years, 85.8% of these patients eventually satisfied also the previous (2010) criteria. Conclusions: Application of the 2017 revisions of McDonald criteria results in an earlier diagnosis of MS in a large percentage of CIS patients destined to convert to MS.

KW - Adult

KW - Biomarkers

KW - Clinically isolated syndrome

KW - Conversion

KW - Demyelinating Diseases

KW - Diagnostic criteria

KW - Dissemination in space

KW - Dissemination in time

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Immunologic Factors

KW - Magnetic Resonance Imaging

KW - Male

KW - Multiple sclerosis

KW - Oligoclonal bands

KW - Retrospective Studies

KW - Symptomatic gadolinium enhancing lesion

KW - Time Factors

KW - Adult

KW - Biomarkers

KW - Clinically isolated syndrome

KW - Conversion

KW - Demyelinating Diseases

KW - Diagnostic criteria

KW - Dissemination in space

KW - Dissemination in time

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Immunologic Factors

KW - Magnetic Resonance Imaging

KW - Male

KW - Multiple sclerosis

KW - Oligoclonal bands

KW - Retrospective Studies

KW - Symptomatic gadolinium enhancing lesion

KW - Time Factors

UR - http://hdl.handle.net/10807/171795

U2 - 10.1007/s00415-018-9048-8

DO - 10.1007/s00415-018-9048-8

M3 - Article

SN - 0340-5354

VL - 265

SP - 2684

EP - 2687

JO - Journal of Neurology

JF - Journal of Neurology

ER -

2017 revisions of McDonald criteria shorten the time to diagnosis of multiple sclerosis in clinically isolated syndromes

Abstract

Keywords

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